Sebacic acid is an intermediate product of ��- oxidation of long-chain aliphatic acids. Catalogue Number Availability Packaging Qty/Pack Price text.skipToContent text.skipToNavigation. Property Value Probability; Human Intestinal Absorption + 0.5731: Blood Brain Barrier + 0.7397: Caco-2 permeable-0.6412: P-glycoprotein substrate However works on polyesters of sebacic acid are rare. Sebacic Acid Safety Data Sheet According to Federal Register / Vol. Sebacic Acid is a white flake or powdered crystal. Compared with short-chain aliphatic acid, sebacic acid is more suitable for the preparation of polyesters, as short-chain aliphatic acids always conduce to intramolecular condensation. Currently, SA is produced exclusively from alkaline pyrolysis of castor oil. Sebacic acid is produced from castor oil by cleavage of ricinoleic acid, which is obtained from castor oil. Solubility Slightly soluble in water. Sebacic acid (SA) is an aliphatic ten-carbon dicarboxylic acid (1,10-decanedioic acid) with a variety of industrial applications, including the production of plasticizers, lubricants, cosmetics, and plastics. Sebacic acid is a naturally occurring dicarboxylic acid with the formula (CH2)8(CO2H)2. A process for preparing sebacic acid by reacting in a first step (i) linoleic acid with water catalyzed by an oleate hydratase to form 10-hydroxy-12-octadecenoic acid, … Other names. Sebacic Acid Safety Data Sheet According to Federal Register / Vol. Degree of solubility in water: 1 g/l 20 °C: Solubility (very soluble in) Alcohol: It has wide industrial uses as a coolant, plasticizer, lubricant, hydraulic fluid, cosmetic, candle, and others. 2. - Find MSDS or SDS, a COA, data sheets and more information. PGS has a linear degradation profile via surface erosion, is completely bioresorbable, and its macroporous structure is well suited for cellular infiltration, paracrine signaling, and neotissue formation.81,82 Chen and colleagues reported that the elastomeric properties of PGS scaffolds render it a promising implant for use in myocardial tissue engineering applications. DESCRIPTION & APPLICATIONS Sebacic Acid is a white flake or powdered crystal. Sebacic Acid Skin Not Available Eyes Not Available Respiratory LC50 Inhalation - rat - > 4,500 mg/m3 Ingestion Not Available Carcinogenicity IARC No components of this product present at levels greater than or equal to 0.1% is identified as probable, possible or ��� Sebacic acid 111-20-6 Sebacic acid 1,3,5-triazine-2,4,6-triamine salt 31970-90-8 Sebacic acid 1,3,5-triazine-2,4,6-triamine salt 94159-18-9 Sebacic acid 2,2',2''-nitrilotriethanol complex 94202-16-1 Sebacic acid 2,2',2 85030-06-4 Regd. Sebacic acid for synthesis. Disposal considerations About Sebacic Acid Sebracic acid is a white powdered crystal that is resolved in ethanol and ether, and it possess low water solubility. SEBACIC ACID reacts exothermically to neutralize bases, both organic and inorganic. Sebaceus is Latin for tallow candle, sebum is Latin for tallow, and refers to its use in the manufacture of candles. - Find MSDS or SDS, a COA, data sheets and more information. It is a white flake or powdered solid. Sebacic Acid PGS has a linear degradation profile via surface erosion, is completely bioresorbable, and its macroporous structure is well suited for cellular infiltration, paracrine signaling, and neotissue formation.81,82 Chen and colleagues reported that the elastomeric properties of PGS scaffolds render it a promising implant for use in myocardial tissue engineering applications. [3], Sebum is a secretion by skin sebaceous glands. SEBACIC ACID FOR SYNTHESIS Safety Data Sheet www.lobachemie.com 09/04/2015 2/8 Adverse physicochemical, human health and environmental effects No additional information available 2.2. Telaglenastat (CB-839) New Telaglenastat (CB-839) is a potent, selective, and orally bioavailable glutaminase inhibitor with IC50 of 24 nM for recombinant human GAC. 111-20-6. Registration dossier . Sebacic acid Revision Date 18-Jan-2018 (Brachydanio rerio) Persistence and DegradabilitySoluble in water Persistence is unlikely based on information available. CopyCopied, CSID:5004, http://www.chemspider.com/Chemical-Structure.5004.html (accessed 23:35, Jan 8, 2021) In patients with multiple acyl-CoA-dehydrogenase deficiency (MADD), also known as glutaric aciduria type II (GAII), a group of metabolic disorders due to deficiency of either electron transfer flavoprotein or electron transfer flavoprotein ubiquinone oxidoreductase, biochemical data shows an increase in urine sebacic acid excretion. Sigma-Aldrich offers a number of Sebacic acid products. Combustible. CAS 111-20-6, EC Number 203-845-5, chemical formula HOOC(CH₂)₈COOH. The castor oil is treated with caustic soda at high temperature, e.g. It is a white flake or powdered solid. A process for preparing sebacic acid comprising in a first step reacting (i) linoleic acid with water catalyzed by an oleate hydratase to form 10-hydroxy-12-octadecenoic acid, in a second step (ii) pyrolysing the 10-hydroxy-12-octadecenoic acid to 1-octene and 10-oxo-decanoic acid, and in a third step (iii) oxidizing the 10-oxo-decanoic acid to sebacic acid. [2], It can also be obtained from decalin via the tertiary hydroperoxide, which gives cyclodecenone, a precursor to sebacic acid. Contact Supplier High quality Sebacic Acid Disodium Salt Supplier Abstract. Sebacic Acid was named from the Latin sebaceus (tallow candle) or … Sebacic acid is a normal urinary acid. Label elements Labelling according to Regulation (EC) No. Other identifiers. Sebacic acid is a derivative of castor oil.[2]. and has antitumor activity. Sebacic acid is a derivative of castor oil. Sebaceus is Latin for tallow candle, sebum is Latin for tallow, and refers to its use in the manufacture of candles. Sebacic acid is a normal urinary acid. [4][5] Included in the free fatty acid secretions in sebum are polyunsaturated fatty acids of which sebacic acid is a major component. Gujarat India. Water solubility Solubility in organic solvents / fat solubility Surface tension Flash point Auto flammability Flammability Explosiveness Oxidising properties Oxidation reduction potential Stability in organic solvents and identity of A weak synergistic effect was found for sebacic acid + ethanol + water mixed systems. In patients with multiple acyl-CoA-dehydrogenase deficiency (MADD) or glutaric aciduria type II (GAII) are a group of metabolic disorders due to deficiency of either electron transfer flavoprotein or electron transfer flavoprotein ubiquinone oxidoreductase, biochemical data shows an increase in urine sebacic acid excretion. It is suggested that sebacic acid is converted to its 5-oxo analog during, and thereby stimulates pro-inflammatory cells to contribute to the worsening of, various inflammatory skin conditions. The solubility of sebacic acid in subcritical water was investigated. Sebacic acid is an alpha,omega-dicarboxylic acid that is the 1,8-dicarboxy derivative of octane. To detect the synergistic effect, solubilities of sebacic acid in 14.35 %, 36.97 %, 79.81 %, and 90.00 % mole fraction ethanol aqueous solution were determined to supplement our previous report. View information & documentation regarding Sebacic acid, including CAS, MSDS & more. 2. The product is described as non-hazardous, though in its powdered form it can be prone to flash ignition (a typical risk in handling fine organic powders). C(CCCCC(=O)O)CCCC(=O)O Slightly soluble in water. SEBACIC ACID - GRANULAR May 13, 2010 Page 3 of 5 ===== HANDLING & STORAGE ===== HANDLING AND STORAGE: Use with adequate ventilation. Sebacic Acid. Safety Data Sheet (Sebacic Acid) DATE PREPARED: 1/20/2016 Page 6 of 6 Section 16. Human neutrophils can convert sebacic acid to its 5-oxo analog, i.e.5-oxo-6E,8Z-octadecaenoic acid (5-oxo-ODE). Sebacic acid (CAS NO.111-20-6) is a low toxic substance, with flammability, burning will produce toxic fumes, so it should be stored in cool and dry environment, dry powder, foam, sand, carbon dioxide, water mist can be used if The solubility in 95% ethanol (100ml) is 11.7g. SEBACIC ACID reacts exothermically to neutralize bases, both organic and inorganic. Sebaceus is Latin for tallow candle, sebum is Latin for tallow, and refers to its use in the manufacture of candles. Mobility Will likely be mobile in the environment due to its water solubility. Sebacic acid is a naturally occurring dicarboxylic acid with the formula (CH 2) 8 (CO 2 H) 2.It is a white flake or powdered solid. SEBACIC ACID: ICSC: 1685: 1,10-Decanedioic acid 1,8-Octanedicarboxylic acid Decanedioic acid: April 2008 Decanedioic acid sodium salt TOP1 supplier Cas No: 17265-14-4 USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Hangzhou Dayangchem Co., Ltd. Avoid contact with skin and eyes. CopyCopied, InChI=1S/C10H18O4/c11-9(12)7-5-3-1-2-4-6-8-10(13)14/h1-8H2,(H,11,12)(H,13,14) SEBACIC ACID 1 Physical and Chemical Fuction: Molecular Formula: HOOC(CH2)8COOH Molecular Weight: 202.25 It is white powder crystal, slightly dissolves in water, completely dissolved in ethanol or ether, but not in benzene. Lookchem Provide Cas No.17265-14-4 Basic information: Properties,Safety Data,Sds and Other Datebase. Mobility Will likely be mobile in the environment due to its water solubility. Sebacic acid for synthesis. Other Information Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. It has wide industrial uses as a coolant, plasticizer, lubricant, hydraulic fluid, cosmetic, candle, and others. PubChem ChemSpider SMILES 3400 mg/kg (大鼠经口) [5] 6000 mg/kg (小鼠经口) [5] 若非注明，所有数据均出自一般条件（25 ，100 kPa）下。 It is resolved in ethanol, ether and soluble slightly in water. Sebacic acid is a derivative of castor oil. 77, No. Incompatible with strong oxidizingagents, bases, reducing agents. It is a white flake or powdered solid. Sebacic acid is a naturally occurring dicarboxylic acid with the formula (CH 2) 8 (CO 2 H) 2.It is a white flake or powdered solid. Sebacic acid is normally made from castor oil, which is essentially glyceryl ricinoleate. Diesters of sebacic acid find various applications as plasticizers, solvents and lubricants. Sebacic acid is a dicarboxylic acid with structure (CH 2) 8 (COOH), and is naturally occurring. Solubility results of sebacic acid were observed to be highly correlated with quadratic model according to analysis of variance. Solubilities of sebacic acid in binary ethanol + water solvent mixtures were measured by the dynamic method using a laser monitoring observation technique at a … An alpha,omega-dicarboxylic acid that is the 1,8-dicarboxy derivative of octane. Sebacic acid: ��ε�� ��������� 1,8 ... Foti, C.; Sammartano, S. Solubility and Activity Coefficients of Acidic and Basic Nonelectrolytes in Aqueous Salt Solutions. Bioaccumulation/ AccumulationNo information available. Currently, SA is produced exclusively from alkaline pyrolysis of castor oil. Material Safety Data Sheet Sebacic acid sc-215843 Hazard Alert Code Key: EXTREME HIGH MODERATE LOW Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME Sebacic acid STATEMENT OF HAZARDOUS NATURE CONSIDERED A HAZARDOUS SUBSTANCE ACCORDING TO OSHA 29 CFR 1910.1200. Sebacic acid (8CI) Registration dossier . [4,9] Poly( Ethylene Display Name: Sebacic acid EC Number: 203-845-5 EC Name: Sebacic acid CAS Number: 111-20-6 Molecular formula: C10H18O4 IUPAC Name: decanedioic acid One of the largest uses of Sebacic Acid is in the manufacture of Nylon 6-10. Main Use: Component log Pow Decanedioic acid 1.5 13. Sebacic acid is a naturally occurring dicarboxylic acid with the formula (CH2)8(CO2H)2. Organic Compound; Plasticizer; Food Toxin; Metabolite; Cosmetic Toxin; Industrial/Workplace Toxin; Animal Toxin; Natural Compound, ORL-RAT LD50 3400 mg kg-1, ORL-MUS LD50 6000 mg kg-1, P261; P280; P302+P352; P304+P340; P305+P351+P338; P312, P261-P280-P305+P351+P338-P304+P340-P405-P501a. It has a role as a human metabolite and a plant metabolite. Sebacic acid is also found in other lipids that coat the skin surface. Sebaceus is Latin for tallow candle, sebum is Latin for tallow, and refers to its use in the manufacture of candles. Sebacic Acid Skin Not Available Eyes Not Available Respiratory LC50 Inhalation - rat - > 4,500 mg/m3 Ingestion Not Available Carcinogenicity IARC No components of this product present at levels greater than or equal to 0.1% About Sebacic Acid Sebracic acid is a white powdered crystal that is resolved in ethanol and ether, and it possess low water solubility. 5-Oxo-ODE is a structural analog of 5-oxo-eicosatetraenoic acid and like this oxo-eicosatetraenoic acid is an exceptionally potent activator of eosinophils, monocytes, and other pro-inflammatory cells from humans and other species. An alpha,omega-dicarboxylic acid that is the 1,8-dicarboxy derivative of octane. Office : Sebacic India Limited 301 World Trade Center, Sayajigunj, Vadodara - 390 005. 77, No. CopyCopied, CXMXRPHRNRROMY-UHFFFAOYSA-N It is resolved in ethanol, ether and soluble slightly in water. CopyCopied, Validated by Experts, Validated by Users, Non-Validated, Removed by Users, Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, Predicted data is generated using the US Environmental Protection Agency’s EPISuite™, Click to predict properties on the Chemicalize site, For medical information relating to Covid-19, please consult the, https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:41865, ACD/Labs Percepta Platform - PhysChem Module, US Environmental Protection Agency’s EPISuite™, Compounds with the same molecular formula, Search Google for structures with same skeleton, 295 deg C / 100 mm (400.5825 °C / 760 mmHg), 295 °C / 100 mm (400.5825 °C / 760 mmHg), 294.5 °C / 100 mmHg (399.9979 °C / 760 mmHg). CAS 111-20-6, EC Number 203-845-5, chemical formula HOOC(CH���)���COOH. Sebacic acid (SA) is an aliphatic ten-carbon dicarboxylic acid (1,10-decanedioic acid) with a variety of industrial applications, including the production of plasticizers, lubricants, cosmetics, and plastics. Stable. �����щ�� ��ъ�⑹����� 留�寃� ��ъ�댄�몃�� ��ㅼ�������� ��ъ�⑹��媛� ��ъ�댄�몃�쇰낫��� ���������寃� ��댁�⑺�� ��� ������濡� 荑���ㅻ�� ��ъ�⑺�⑸�����. : Rinse cautiously with water for several minutes. Sebacic acid, a 10 carbon containing dicarboxylic acid (DCA), is an important precursor in the production of nylon and polyamides (PAs), primarily PA-4,10 and PA-5,10 (Chung et al. Sebacic acid is a naturally occurring dicarboxylic acid with the formula (CH2)8(CO2H)2. Sebacic Acid. Bioaccumulation/ AccumulationNo information available. CB-839(Telaglenastat) inudces autophagy and has antitumor activity. Sebacic acid is a derivative of castor oil. Sebacic acid is a derivative of castor oil. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. Sebaceus is Latin for tallow candle, sebum is Latin for tallow, and refers to its use in the manufacture of candles. The castor oil is treated with caustic soda at high temperature, for example 250 C, so that saponification, leading to the formation of ricinoleic acid, is followed by a reaction giving sebacic acid and octan-2-ol: 58 / Monday, March 26, 2012 / Rules and Regulations 10/12/2015 EN (English US) 2/5 First-aid Measures After Eye Contact: Rinse cautiously with water for several minutes. It is a conjugate acid of a sebacate (2-) and a sebacate. Structure, properties, spectra, suppliers and links for: Sebacic acid, 111-20-6. Herein, we present an e Octanol is a byproduct. Applications Sebacic acid is used as a monomer for nylon 610, plasticizers, lubricants, hydraulic fluids, cosmetics and candles. Sebacic acid: Overview. Approximation models were employed for determining solubility of sebacic acid at elevated temperatures. We also Provide Trading Suppliers & Manufacture for 17265-14-4 SEBACIC ACID ��� CAS number. Herein, we present an e 1272/2008 [CLP] Extra labelling to displayExtra classification(s) to display Sublimes slowly at 750 mm Hg when heated to melting point. Sebacic Acid was named from the Latin sebaceus (tallow candle) or sebum (tallow) in reference to its use in the manufacture of candles. Registrant / Supplier Registered Updated 3M Belgium BVBA/SPRL Hermeslaan 7 1831 Diegem Belgium 2016 [Confidential] ARKEMA CASDA 420 rue d'Estienne d'Orves 92700 Colombes France 2010 ARKEMA FRANCE 420 rue d'Estienne d'Orves 92700 COLOMBES France Solubility Show More Product # Description 283258 Sebacic acid, 99%, 84809 Sebacic acid, ≥95.0% (GC), 8.00753 Sebacic acid, for synthesis, Sorry we cannot compare more than 4 products at a time. This action is mediated by the OXER1 receptor on these cells. Wash thoroughly after handling. Sebazinsaeure. Solubility in water: 0.25 g/L[1] 遺����援ъ“��� (HOOC)(CH2)8(COOH)��� ��댁�쇨린��곗�쇰�� ��쇳�댁�� ��곗��(���珥�瑜� 留���ㅻ�� 寃�)瑜� ��삵����� sebum������ ������������ sebacic acid濡� 紐�紐���������쇰ʼn �����댄��吏� ������ 寃���쇰�� �����ㅼ�� 遺�留���������대�� 誘몄�몃��吏���� 諛������������� ������. 1. May react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. May react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. In the industrial setting, sebacic acid and its homologues such as azelaic acid can be used as a monomer for nylon 610, plasticizers, lubricants, hydraulic fluids, cosmetics, candles, etc. It is a waxy set of lipids composed of triglycerides (≈41%), wax esters (≈26%), squalene (≈12%), and free fatty acids (≈16%). Sebacic acid is normally made from castor oil, which is essentially glyceryl ricinoleate. Response surface methodology was used to study the combined effects of the different parameters such as temperature, static and dynamic time to optimize the process conditions for the maximum solubility of sebacic acid. [6], InChI=1S/C10H18O4/c11-9(12)7-5-3-1-2-4-6-8-10(13)14/h1-8H2,(H,11,12)(H,13,14), InChI=1/C10H18O4/c11-9(12)7-5-3-1-2-4-6-8-10(13)14/h1-8H2,(H,11,12)(H,13,14), Except where otherwise noted, data are given for materials in their, Ullmann's Encyclopedia of Industrial Chemistry, "Mammalian Wax Biosynthesis II: Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family", https://en.wikipedia.org/w/index.php?title=Sebacic_acid&oldid=999055436, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License, 131 to 134.5 °C (267.8 to 274.1 °F; 404.1 to 407.6 K), This page was last edited on 8 January 2021, at 07:53. 250°C, so that saponification, leading to the formation of ricinoleic acid; is followed by a reaction giving sebacic acid and octan-2-ol Figure 18.5. , including cas, MSDS & more and more sebacic acid solubility a monomer for nylon 610, plasticizers solvents! 8 ( CO2H ) 2 health and environmental effects No additional information available 2.2 of. 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Ec Number 203-845-5, chemical formula HOOC ( CH₂ ) ₈COOH, bases, both organic and.. ) inudces sebacic acid solubility and has antitumor activity 5-oxo analog, i.e.5-oxo-6E,8Z-octadecaenoic acid ( )... & manufacture for 17265-14-4 sebacic acid is a white flake or powdered crystal found for acid. And ether, and it possess low water solubility mobile in the environment due to its use the! With active metals to form gaseous hydrogen and a plant metabolite industrial uses a... Solubility results of sebacic acid is produced exclusively from alkaline pyrolysis of oil! Ethanol ( 100ml ) is 11.7g human health and environmental effects No additional information 2.2. Made from castor oil, which is obtained from castor oil, which essentially! % ethanol ( 100ml ) is 11.7g ], sebum is Latin tallow! At high temperature, e.g crystal that is resolved in ethanol, ether and soluble slightly in.. Ethylene sebacic acid reacts exothermically to neutralize bases, both organic and inorganic in other that.

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