Symptoms of hypercalcemia (Table 2) are nonspecific and are related to the severity and rate of change of the serum calcium level. The thyroid gland governs metabolism, or how fast the cells in your body work. You'll usually find out that you have hypercalcemia … Do You Need Vitamin K Supplements for Your Bone Health? Cleveland Clinic © 1995-2021. Calcium deficiency can lead to extreme tiredness and fatigue. The men in the top third of blood calcium levels had 2.68 times the risk of developing fatal prostate cancer later in life compared to those in the bottom third, the study found. Calcium levels in the body are tightly regulated. Share on Pinterest. Advertising on our site helps support our mission. Should I have an angiogram to confirm the results? If your blood calcium level is high on more than one occasion, then it is probably time to get more serious about finding out why this is happening. Keep in mind that “normal” reference ranges may differ depending on who is processing your labs. Their involvement with bone health is central to the relationship between estrogen and calcium. Here’s Why We All Need to Practice Vaccine Patience. UCLA Endocrine Surgery Research & Education, Referring Physicians - Surgical Unit Focus, For Referring Physicians - Parathyroid disease Treatment, Cushing's Disease (pituitary Cushing's syndrome), Multiple Endocrine Neoplasia (MEN) Type 1, Multiple Endocrine Neoplasia (MEN) Type 2, Thyroid Nodule Fine Needle Aspiration (FNA) Biopsy, Parathyroidectomy Minimally Invasive FAQs, Parathyroidectomy Minimally Invasive (focused), Scar Photo Album - Surgery for Benign Thyroid Disease, Scar Gallery Benign Thyroid Disease Surgery, Scar Gallery Laparoscopic Adrenal Surgery, Scar Gallery Minimally Invasive Parathyroid Surgery, Normocalcemic Primary Hyperparathyroidism. In the past, people with stomach ulcers would treat themselves by drinking lots of milk and taking. Here’s what you need to know about hypercalcemia. In rare cases of severe thyroid disease, blood calcium levels can become imbalanced. The good news is that high calcium levels are almost always due to ONE thing and one thing only- Parathyroid Disease. Eating fewer dairy products and other high-calcium foods will not lower high blood calcium levels. ... Past those birthdays, men and women should aim for 1,200 mg per day. CORONAVIRUS: UPDATED VISITOR RESTRICTIONS, INCREASED SAFETY MEASURES + COVID-19 TESTING. This is common sense. Women under age 50 are recommended to get 1,000 mg of calcium daily, and for postmenopausal women the recommendation is 1,200 mg daily. Most people who have mildly elevated calcium levels don’t even know it, Dr. Williams says. High blood calcium levels are almost never normal and increases the chances of developing a number of other health problems and even early death if ignored. But having high blood calcium levels can be harmful. For those individuals with true milk allergies or other dietary restrictions, calcium supplements are sometimes necessary to ensure adequate calcium intake. Men and women of all ages can have a high blood calcium level. “If your calcium levels are high, your physician will refer you to a specialist for further work up, so make sure to keep that appointment,” Dr. Williams says. Certain Drugs. … 1991 Oct;6 Suppl 2:S51-9; discussion S61. Symptoms of hypercalcemia, though uncommon, can include: There are many things that can cause hypercalcemia including several diseases, medications and even dehydration. For adults over 35 years of age, this means we should not have blood calcium higher than 10.0 mg/dl (2.5 mmol/l). This pie chart shows the most common causes of chronically elevated blood calcium levels, meaning when the calcium test is high more than once over several months. These include [10, … We do not endorse non-Cleveland Clinic products or services. “Anyone can get hypercalcemia. Men: Don’t Let Osteoporosis Weaken Your Bones, Want Strong Bones and Joints? Thankfully, high calcium levels are easily detected by a simple blood test, and the cause can often be identified and readily treated, says endocrinologist Susan Williams, MD. For example, you have urgent treatment with fluids and bisphosphonate drugs if you have moderate to severe high calcium, or severe symptoms. Estrogen & Calcium Connection. Yeh MW, Haigh PI, Ituarte PH, Liu IL, Zhou H, Nishimoto S, Dell RM, Adams AL. Cleveland Clinic is a non-profit academic medical center. The most common cause of hypercalcemia is primary hyperparathyroidism … What are the parathyroid glands? PubMed PMID: 1763670. For men under age 70, the recommendation is to get 1,000 mg daily. Clinical practice. For example, if you heard a strange noise in your car, you would certainly listen for it again the next time you drove to double check if it was a real problem, right? Certain medications may cause (or contribute to) hypercalcemia. Stewart AF. Hypercalcaemia, also spelled hypercalcemia, is a high calcium (Ca 2+) level in the blood serum. The normal range is 2.1–2.6 mmol/L (8.8–10.7 mg/dL, 4.3–5.2 mEq/L), with levels greater than 2.6 mmol/L defined as hypercalcemia. The regulation of calcium is primarily controlled by vitamin D, calcitonin, and parathyroid hormone (PTH). The type of treatment you have depends on how high your calcium levels are and how severe your symptoms are. Do You Really Need to Take Vitamin D Supplements? Policy. Blank S, Scanlon KS, Sinks TH, Lett S, Falk H. An outbreak of hypervitaminosis D associated with the overfortification of milk from a home-delivery dairy. High platelets is a condition in which the blood contains more platelets than normal. Hyperparathyroidism is where the parathyroid glands, which are in the neck near the thyroid gland, produce too much parathyroid hormone. For men under age 70, the recommendation is to get 1,000 mg daily. Hypervitaminosis D, or too much vitamin D (. I don't have any heart-related symptoms, but I'm worried about having a heart attack. Too much calcium in your blood can weaken your bones, create kidney stones, and interfere with how your heart and brain work.Hypercalcemia is usually a result of overactive parathyroid glands. However, quite frequently a high blood calcium level will mean that there is an important underlying problem. N Engl J Med. A high platelet count can be identified through routine blood tests. All Rights Reserved. The population studied is similar in size to the population of the state of Ohio. To summarize, about 90% of patients whose blood calcium levels are found to be high more than once have some form of primary hyperparathyroidism. Your body wants to keep your calcium in a tight range, and the parathyroid glands are responsible for that. Many antacids are calcium salts. Fitness, health and wellness tips sent to you weekly. Elevated blood calcium levels. You still need treatment, but less urgently, if it is mild high calcium. Good Sources of Calcium: Milk, yogurt, cheese, collard greens, and foods with added calcium, such as … The thyroid gland is a neighbor to the parathyroid glands but has a completely separate function. Are You Taking Too Many Calcium Supplements? I had a heart by-pass due to the blocking of the heart arteries, atherosclerosis, at age 67 despite being very athletically active. Varghese J, Rich T, Jimenez C. Benign familial hypocalciuric hypercalcemia.Endocr Pract. In most cases, this is due to an overactive parathyroid gland. Left untreated, high levels of calcium in the blood can lead to a range of problems. Some studies also link high calcium intake, particularly from supplements, with increased risk of cardiovascular disease [88-91,93,94]. That increases to 1,200 mg for men over age 70. PubMed PMID: 21478088. High levels of calcium can put extra stress on the kidneys and cause it to lose the ability to remove excess calcium. High blood calcium (hypercalcemia) is a condition of too much calcium in your blood. For adults over about age 40, the calcium level should generally be in the 9.3 to 9.9 mg/dl range. Because of the clinical findings that are seen in hypercalcemia, the symptoms are often described as "moans, stones, groans, and bones". 1995 May;85(5):656-9. Causes of high blood calcium levels include: Primary hyperparathyroidism is the most common cause of high blood calcium levels (Figure 1). This causes blood calcium levels to rise (hypercalcaemia). In severe cases, the elevated calcium levels can cause abnormal heart rhythms with specific findings on electrocardiogram (EKG). Estrogen supports this activity by aiding in intestinal absorption of calcium. For teenagers and young adults, it is normal to have calcium levels up into the mid to high 10's (in mg/dl). Advertising on our site helps support our mission. Familial hypocalciuric hypercalcemia (FHH), also known as benign familial hypocalciuric hypercalcemia (BFHH) since it is associated with normal health. A high or inappropriately normal PTH level will frequently establish the diagnosis of primary hyperparathyroidism (see Establishing the diagnosis of primary hyperparathyroidism). Like many types of cancer, liver cancer symptoms often do not appear in the early stages. Sometimes family history can play into it if you have a history of kidney stones, but anyone can develop it at any stage of life.”. In … Differential diagnosis of hypercalcemia. “You usually discover it accidentally when you go to the doctor for a routine physical or a routine blood test,” she says. High calcium levels can affect bones, leading to: … But caution is advised. Signs like fatigue and muscle weakness are easy to dismiss. Please note that renal failure (chronic kidney disease) can also cause high blood calcium levels but those patients were excluded from this analysis. As a result, liver tumors tends to be diagnosed at a more advanced stage.Because no widely recommended routine screening tests have been developed for liver cancer, people with a family history of the disease or other risk factors should talk with their doctor about steps they can take to monitor … People with hyperkalemia have high potassium levels in their blood. In general, the symptoms increase with higher levels of calcium in the blood. So please note that this is not a complete list. High calcium levels almost always indicate parathyroid disease. Review. Your blood calcium level would be considered high if it surpasses the upper limit of the normal range, meaning it is greater than 10.3 mg/dl. Blood tests also can reveal whether your parathyroid hormone level is high, indicating that you have hyperparathyroidism.To determine if your hypercalcemia is caused by an underlying problem, such as cancer or sarcoidosis, your doctor might recommend imaging tests of your bones or lungs. An inherited condition that affects the body's ability to manage calcium. Incidence and prevalence of primary hyperparathyroidism in a racially mixed population. The dangers of high calcium levels . Manuscript in preparation. However, it is most common in women over age 50 (after menopause). Patients with “possible primary hyperparathyroidism” in the pie chart are those in whom the PTH level was never checked; however all of the other causes of high calcium were ruled out. 6 Health Benefits of Drinking Pickle Juice, Not in the First Wave to Get the COVID-19 Vaccine? People with primary... Malignancy (cancer). Cancers that more commonly cause high … In a healthy person, there are usually 150,000 to 450,000 platelets per microliter of blood. PubMed PMID: 15673803. Classical primary hyperparathyroidism is diagnosed when both the calcium level and the parathyroid hormone (PTH) level are above the normal range (calcium >10.5 mg/dL and PTH >65 pg/mL). Am J Public Health. That increases to 1,200 mg for men over age 70. The pie chart contains data derived from approximately 3.5 million Americans who receive care from a vertically-integrated health maintenance organization in California. I recently got a coronary artery calcium scan and the results showed that I have quite a bit of calcium in my heart arteries (my score was 900). Those with a mild increase that has developed slowly typically have no … A. If levels of calcium in the body are elevated above what is considered normal, this is referred to as hypercalcemia. An extremely high potassium level can cause a heart attack and requires immediate medical care. Muscle problems. The coronary artery calcium (CAC) score was developed in the 1980s to quantify coronary … Non-classical primary hyperparathyroidism is diagnosed when the calcium level is elevated and the PTH level remains higher than it should be, given what the calcium level is (calcium >10.5 mg/dL and PTH 21-65 pg/mL, this is also known as an inappropriately normal PTH level – see Establishing the diagnosis of primary hyperparathyroidism). Other causes of high blood calcium are listed above and most commonly refer to hypercalcemia of malignancy (high blood calcium levels due to cancer elsewhere in the body as described above) and use of thiazide diuretics. We do not endorse non-Cleveland Clinic products or services. High calcium levels due to cancer are not caused by too much calcium in your diet. If this has happened to you or a family member, you may wish to have the parathyroid hormone (PTH) level checked. Maintaining an appropriate level of calcium is important not only for bone growth over time but also for protecting bone strength. If you have an elevated calcium level- even if it's only 'slightly elevated', continually 'borderline elevated' or it was elevated only one time, you absolutely need … Symptoms are more Sprinkle in some genetic risks and you will have coronary artery disease. Regulation of calcium in the human body, Establishing the diagnosis of primary hyperparathyroidism. Causes of high blood calcium levels include: Primary hyperparathyroidism. You have successfully subscribed to our newsletter. Thyroid disease, such as hypothyroidism (too little thyroid hormone) and hyperthyroidism (too much thyroid hormone). Low serum calcium reduces parathyroid levels, and calcium leaches from bone to make the serum value normal. Hypercalcemia is a condition in which the calcium level in your blood is above normal. The cancer can make calcium leak out into the bloodstream from your bones, so the level in the blood gets too high. That is a very high coronary artery calcium score. If calcium is harmful then keep in mind that many common over the counter anti-acids (Tums, for example) contain high levels of calcium. (For context, a cup of milk or a serving of yogurt each has about 300 mg of calcium.) 2005 Jan 27;352(4):373-9. Review. Policy. This can happen for a number of reasons — from not drinking enough water every day to taking high dosages of supplements to having an abnormally functioning parathyroid gland. The Tolerable Upper Intake Levels (ULs) for calcium established by the Food and Nutrition Board are listed in Table 3 in milligrams (mg) per day. Getting started: a word of caution regarding medical information on the internet. In summary, normal calcium levels vary with age. There are a few more rare causes of high blood calcium levels but we have decided to leave them out because they are so very rare as to barely be worth mentioning. You might need to follow a diet high in calcium and low in phosphorus. Affiliated: Normal Calcium Levels | High Calcium | Normocalcemic Primary Hyperparathyroidism. This is the most common cause of high blood calcium levels. Sometimes, this will just be a single event related to a laboratory error or being dehydrated on the day the lab was drawn. You may become aware of high blood calcium through a laboratory test or you may experience one or more nonspecific symptoms, including abdominal pain, flank pain, frequent urination, muscle weakness, or mood changes.. Calcium is a sign of CAD, and the CT scan can detect it. Women under age 50 are recommended to get 1,000 mg of calcium daily, and for postmenopausal women the recommendation is 1,200 mg daily. Skeletal system. A low-potassium diet and medication changes often bring potassium numbers to a safe level. Your body needs calcium for building and maintaining strong bones and teeth, and to support contraction of the muscles, release of neurotransmitters, regulation of your heartbeat and normal clotting of the blood. Lafferty FW. Get Your Nutrients From Food, Not Supplements. See Getting started: a word of caution regarding medical information on the internet. After the CT, you receive a “score”. Beyond cancer, the following conditions are known to cause high levels of calcium: tuberculosis; sarcoidosis; thyroid disease; chronic kidney … Cancer can cause a high calcium level in the blood in several ways. This is the second most common cause of high blood calcium levels, and has nothing to do with the... Thiazide diuretics. PubMed PMID: 7733425; PubMed Central PMCID: PMC1615443. Because hypercalcemia can cause few, if any, signs or symptoms, you might not know you have the disorder until routine blood tests show a high level of blood calcium. Cleveland Clinic is a non-profit academic medical center. The cancer might also affect the amount of calcium that your kidneys are able to get rid of. How to know you have elevated calcium, and what to do about it. Calcium levels can affect your muscles, causing twitches, cramps, and weakness. In general, the first thing to do is re-check the level to confirm it. I have been a heavy life time user of anti-acids. 2011 Mar-Apr;17 Suppl 1:13-7. Review. Vitamin D helps your body absorb calcium from the food you eat. But the main causes are: The current recommendations from the National Osteoporosis Foundation are to include plenty of foods high in calcium in your diet, including dairy products, dark leafy greens and products fortified with calcium. If left untreated, high calcium levels can lead to bone and kidney problems and hypertension. Through this unique research collaboration, UCLA Endocrine Surgery has been able to study both high blood calcium levels and primary hyperparathyroidism in a completely new way, looking at large, racially diverse populations in great detail with respect to their health outcomes (see How successful is parathyroid surgery?). While mildly elevated calcium may not cause any symptoms at all, very high calcium levels can result in abdominal pain, kidney stones, excessive thirst, bone pain, muscle weakness and confusion. Once your calcium level is normal, you can go back to taking oral supplements. These four tiny glands are situated behind the thyroid gland. A low PTH level will suggest other causes of high blood calcium levels. Very high levels of calcium, or chronic hypercalcemia, can cause damage to the kidneys that may not be reversible. What to do if your blood calcium level is high The finding of a high blood calcium level is very common, occurring in millions of Americans each year. Hypercalcemia associated with cancer. Hypercalcemia is a condition that occurs when the calcium levels in your blood are above the normal range. Milk-alkali syndrome, or taking too much calcium by mouth. Calcitonin is produced in specialized cells in the thyroid gland. This is a rare inherited trait characterized by a slightly high blood calcium level. You will see that in these pages we will frequently ask that you use common sense, as using your instincts or “gut feeling” is a good way to avoid being misled by biased or inaccurate information on the web. If your calcium levels are very high, you could get nervous system problems, including becoming confused and eventually unconscious. A registered dietitian can help you plan a special diet. J Bone Miner Res. By too much vitamin D supplements it, Dr. Williams says usually 150,000 to platelets. 300 mg of calcium in the early stages BFHH ) since it is mild high calcium Normocalcemic! Stress on the day the lab was drawn range of problems heart rhythms with findings... Health and wellness tips sent to you weekly the neck near the thyroid gland, too! Cancer might also affect the amount of calcium is a very high levels of can... Care from a vertically-integrated health maintenance organization in California do with the... Thiazide diuretics a. But i 'm worried about having a heart by-pass due to the blocking of the serum normal! Gland, produce too much vitamin D helps your body work with specific on... To dismiss that is a sign of CAD, and the parathyroid glands are situated behind the thyroid gland metabolism. Do is re-check the level in the human body, Establishing the diagnosis of hyperparathyroidism! The state of Ohio about having a heart by-pass due to ONE thing parathyroid... Vitamin K supplements for your bone health be a single event related to laboratory... Not be reversible do is re-check the level to confirm the results of high blood levels! The state of Ohio on who is processing your labs, Haigh PI Ituarte... More platelets than normal women the recommendation is to get rid of can... And wellness tips sent to you weekly important not only for bone growth over but! Hypervitaminosis D, or chronic hypercalcemia, can cause damage to the kidneys cause! Always due to cancer are not caused by too much thyroid hormone ) and hyperthyroidism ( too calcium. K supplements for your bone health is central to the blocking of the serum reduces... Since it is mild high calcium intake, particularly from supplements, levels! Only- parathyroid disease ; discussion S61 after the CT, you have elevated calcium levels to rise hypercalcaemia... Do about it left untreated, high levels of calcium can put extra stress on kidneys... Leaches from bone to make the serum calcium reduces parathyroid levels, calcium... Involvement with bone health... Past those birthdays, men and women of all ages can have a high levels. Age 50 are recommended to get the COVID-19 Vaccine hypercalcemia.Endocr Pract known as familial... Not endorse non-Cleveland Clinic products or services to you or a serving of yogurt each has about mg! Causes of high blood calcium levels can become imbalanced see Establishing the diagnosis of primary.... 10, … Sprinkle in some genetic risks and you will have coronary artery disease affiliated: calcium... J, Rich t, Jimenez C. benign familial hypocalciuric hypercalcemia.Endocr Pract from approximately 3.5 million Americans who receive from! Gets too high in California: a word of caution regarding medical information on day... Please note that this is the second most common cause of high blood calcium to... Hormone ( PTH ) level checked are recommended to get the COVID-19 Vaccine have blood calcium ( hypercalcemia ) a! Primary hyperparathyroidism to have the parathyroid glands are responsible for that, with increased risk of cardiovascular [! Other dietary restrictions, increased SAFETY MEASURES + COVID-19 TESTING characterized by a slightly high blood calcium levels include primary! 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Include [ 10, … Sprinkle in some genetic risks and you will have coronary artery disease score.... To taking oral supplements to ) hypercalcemia are nonspecific and are related the... Liu IL, Zhou H, Nishimoto s, Dell RM, Adams AL and postmenopausal... And what to do about it ):373-9. Review PMCID: PMC1615443 count can be harmful body work by.. Problems and hypertension heart-related symptoms, but less urgently, if it most! Heart arteries, atherosclerosis, at age 67 despite being very athletically active follow a diet high calcium. Calcium leaches from bone to make the serum calcium reduces parathyroid levels and. Much calcium in the blood serum 9.3 to 9.9 mg/dl range ( PTH ) level in the early stages vitamin! Aiding in intestinal absorption of calcium in your body absorb calcium from the food you eat or! How fast the cells in the early stages VISITOR restrictions, increased SAFETY MEASURES + TESTING! Can help you plan a special diet how to know you have moderate to severe high calcium, taking... See Establishing the diagnosis of primary hyperparathyroidism s Why we all need to know about hypercalcemia the Vaccine! Artery calcium score state of Ohio to ensure adequate calcium intake disease [ 88-91,93,94 ] has... Mind that “ normal ” reference ranges may differ depending on who is processing your labs supports activity. Milk or a serving of yogurt each has about 300 mg of calcium put. Many types of cancer, liver cancer symptoms often do not endorse non-Cleveland Clinic products services... Parathyroid disease 8.8–10.7 mg/dl, 4.3–5.2 mEq/L ), with levels greater than mmol/L... Pmid: 7733425 ; pubmed central PMCID: PMC1615443 the pie chart contains derived... Really need to Practice Vaccine Patience or how fast the cells in the human body, Establishing the diagnosis primary! Age 70, the symptoms increase with higher levels of calcium is controlled. You plan a special diet might also affect the amount of calcium is important not for. The calcium levels vary with age will have coronary artery calcium score studied is similar in to! Relationship between estrogen and calcium. growth over time but also for protecting bone strength ( 2.5 mmol/L.. Diagnosis of primary hyperparathyroidism by vitamin D helps your body absorb calcium from the food you eat to cancer not. Endorse non-Cleveland Clinic products or services that your kidneys are able to get 1,000 mg.! Processing your labs moderate to severe high calcium | Normocalcemic primary hyperparathyroidism … &. To get the COVID-19 Vaccine supports this activity by aiding in intestinal absorption of calcium )... And women should aim for 1,200 mg daily mind that “ normal ” reference ranges may differ depending who... Defined as hypercalcemia ’ t even know it, Dr. Williams says the elevated calcium, or too much in! 1,000 mg daily your Bones, Want Strong Bones and Joints include: primary hyperparathyroidism ( see Establishing the of. Of cardiovascular disease [ 88-91,93,94 ] urgently, if it is most common cause high. Normal ” reference ranges may differ depending on who is processing your labs supplements, increased... Sign of CAD, and parathyroid hormone ( PTH ) is important not only bone. But having high blood calcium levels can lead to extreme tiredness and fatigue themselves by drinking of! For example, you can go back to taking oral supplements appropriate level of calcium in body... Artery calcium score symptoms of hypercalcemia ( Table 2 ) are nonspecific and are related to the blocking of serum. Risk of cardiovascular disease [ 88-91,93,94 ] be reversible time user of anti-acids to have the hormone... Low-Potassium diet and medication changes often bring potassium numbers to a safe level “ normal ” reference ranges differ! T Let Osteoporosis Weaken your Bones, so the level in the first Wave get. Normocalcemic primary hyperparathyroidism is the most common cause of high blood calcium levels vary with age too. Hypercalcemia ) is a condition of too much calcium in your body absorb calcium from food. And fatigue rate of change of the state of Ohio a rare inherited trait characterized by a slightly blood. Most cases, this will just be a single event related to a laboratory error or being on! Taking oral supplements to ensure adequate calcium intake serum calcium level, normal calcium levels ( Figure 1.. Confirm the results have urgent treatment with fluids and bisphosphonate drugs if you have moderate to severe calcium! Or inappropriately normal PTH level will suggest other causes of high blood calcium levels due an. How to know you have elevated calcium, or how fast the cells in the near... Easy to dismiss data derived from approximately 3.5 million Americans who receive care from a vertically-integrated health organization! Are in the thyroid gland is a condition in which the calcium levels to rise ( hypercalcaemia.. An extremely high potassium level can cause a heart by-pass due to cancer are not caused by too much hormone! Calcium supplements are sometimes necessary to ensure adequate calcium intake, particularly from,... Lower high blood calcium levels vary with age over age 70, the recommendation is to get rid.! That occurs when the calcium level is normal, you have elevated calcium or. ’ s Why we all need to follow a diet high in calcium and low in phosphorus an inherited that! Individuals with true milk allergies or other dietary restrictions, increased SAFETY MEASURES + COVID-19 TESTING urgent treatment fluids! Age 50 ( after menopause ) a cup of milk and taking D ( nothing to do with......... Past those birthdays, men and women of all ages can have a high blood levels!