Aggressive management of brain metastases is effective in both symptom palliation and prolonging the life. From 2002 to 2006, a retrospective analysis was made from 250 unselected consecutive patients with secondary brain metastases from lung cancer, breast cancer and melanoma. Cancer: principles and practice of oncology. However, the two Kaplan-Meier curves were not statistically significantly different, p = 0.13. In those patients with a single intracerebral metastasis and minimal tumor burden, the type of treatment used had a significant impact on survival. An icon used to represent a menu that can be toggled by interacting with this icon. 2020 - สำรวจบอร์ด "สาวเกาหลี" ของ นิภาพร คงมั่น บน Pinterest ดูไอเดียเพิ่มเติมเกี่ยวกับ สาวชนบท, หมวกผู้หญิง, ผู้หญิง Verified Purchase. To evaluate whether high biologically effective dose (BED) radiotherapy improves local control and survival outcomes for patients with brain metastases (BMs) from small-cell lung cancer (SCLC) and to determine possible prognostic factors. Love for Prim Chanikarn Tangabodi. The most common WBRT schedule is 30 grays (Gy) in 10 fractions. One hundred seventy-one patients were eligible: eighty-six in arm A and eighty-five in arm B; none had received prior chemotherapy; seventy-six and seventy-three, respectively, were assessable for response. On subgroup analysis of patients who had other tumor types, the 1-year LC rate was 31% after 30 Gy and 45% after 40 Gy (P = .26); and the 1-year OS rate was 52% and 59%, respectively (P = .08). Using 10 × 3 Gy in 2 weeks is the standard regimen in most centers. A retrospective study of patients with cytologically and histologically diagnosed NSCLC and brain metastasis detected by cranial computed tomography or magnetic resonance imaging was performed. There was no significant difference by treatment arm in survival (median, 5.2 months for MGd v 4.9 months for WBRT; P =.48) or time to neurologic progression (median, 9.5 months for MGd v 8.3 months for WBRT; P =.95). Intracranial metastases: current management strategies. (p<0.05). The first PH based supporting Thai actress @primiily Recognized and approved by official fanclub @primiily.official In: DeVita V, Hellman S, Rosenberg SA, editors. Mayo Foundation for Medical Education and Research, Universitätsklinikum Schleswig - Holstein, A Specific Survival Score for Patients Receiving Local Therapy for Single Brain Metastasis from a Gynecological Malignancy, Re-administration of Chemotherapy in Patients with Advanced Non-small Cell Lung Cancer Who Recovered from Chemotherapy-induced Interstitial Lung Disease, Current Management of Metastatic Brain Disease, The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: A systematic review and evidence-based clinical practice guideline, Dose-escalation of whole-brain radiotherapy for brain metastasis in patients with a favorable survival prognosis, High Biologically Effective Dose Radiotherapy for Brain Metastases May Improve Survival and Decrease Risk for Local Relapse Among Patients With Small-Cell Lung Cancer: A Propensity-Matching Analysis, Brain metastases in HER2-positive breast cancer: The evolving role of lapatinib, Role of Palliative Radiotherapy in Brain Metastases, Surgical Brain Metastases: Management and Outcome Related to Prognostic Indexes: A Critical Review of a Ten-Year Series, 3D Radiation Therapy Boost Improves the Outcome of Whole Brain Radiation Therapy Treated RPA II Patients with One or Two Brain Metastases, Radiotherapy of brain metastases from breast cancer: Treatment results and prognostic factors, Late Brain Oligometastases Diagnosed at Least 36 Months after Cancer Detection are Associated with Favorable Survival Outcome, Survival and quality of life after whole brain radiotherapy with 3D conformal boost in the treatment of brain metastases, Outcomes After Whole-brain Radiotherapy for Brain Metastases with 5×4 Gy: Importance of Overall Treatment Time, Observed Effects of Whole-Brain Radiation Therapy on Focused Ultrasound Blood–Brain Barrier Disruption, Dose Escalation in Patients Receiving Whole-Brain Radiotherapy for Brain Metastases from Colorectal Cancer, Resource Utilization in Patients with Brain Metastases Managed with Best Supportive Care, Radiotherapy and/or Surgical Resection: A Markov Analysis, Whole brain radiotherapy: Prognostic factors and results of a radiation boost delivered through a conventional linear accelerator, A New Paradigm in Treatment of Brain Metastases, Predicting Survival after Whole-Brain Irradiation for Cerebral Metastases from Prostate Cancer, Strahlentherapie intrazerebraler Metastasen, E18. to a total dose of 54.4 Gy vs. an accelerated fractionation (AF) of 30 Gy in 10 daily fractions in patients with unresected brain metastasis. 4 Issue 3 October - December 2013 The overall results did not demonstrate significant differences by treatment arm for survival and ERC time to neurologic progression. On multivariate analysis, intracerebral control was positively associated with a better Eastern Cooperative Oncology Group performance score (ECOG-PS) (p<0.001). When a patient with cancer develops a brain metastasis, death is usually imminent, but aggressive treatment in some patients with limited or no systemic disease yields long-term survival. Background/aim: A boost of 22.4 Gy in 14 fractions was delivered to each lesion with a 2-cm margin. Methods. 5 × 4 Gy appears preferable for the majority of these patients. DeVita V, Hellman S, Rosenberg SA, editors. In 11 patients, the following factors were retrospectively analyzed for associations with OS: Age, Karnofsky performance score (KPS), tumor type, extra-cranial metastatic sites, and time from diagnosis of gynecological malignancy to treatment of brain metastasis. Treatment with MGd improved time to neurologic progression in patients with lung cancer (median, not reached for MGd v 7.4 months for WBRT; P =.048, unadjusted). The main objective of this prospective multicenter randomised phase III study was to compare a combined regimen of fotemustine plus whole brain irradiation versus fotemustine alone in terms of cerebral response and time to cerebral progression in patients with melanoma brain metastases. Here we retrospectively evaluated whether chemotherapy re-administration (CT-R) was effective in patients after chemotherapy-induced ILD. Of the 779 cases, 773 are dead (99%). Objectives: to evaluate whole brain radiotherapy (WBRT) with 3D conformal boost in brain metastases patients with regard to OS and quality of life. Four of the 75 patients with primary tumour sites in the breast (two patients) and the kidney (two patients) survived for more than 2 years. Level 3 Underpowered class I evidence along with the preponderance of conflicting class II evidence suggests that SRS alone may provide equivalent functional and survival outcomes compared with resection + WBRT for patients with single brain metastases, so long as ready detection of distant site failure and salvage SRS are possible. Eight additional potential prognostic factors were investigated including age, gender, Karnofsky performance score (KPS), tumor type, interval between tumor diagnosis and RT, number of metastases, extracranial metastases, and Recursive Partitioning Analysis (RPA) class. Correspondingly, a large difference in actuarial median survival was observed (39.9 months [95% confidence interval, 16.8-63.0 months] versus 9.7 months (95% confidence interval, 6.1-13.3 months). 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