of patients treated for intracranial metastases with wholebrain irradiation. Treatment was best supportive care (BSC), primary radiotherapy (RT) and/or surgical resection. Conclusion Late dissemination was uncommon. The 1-year survival rate was 19% in the AF arm vs. 16% in the AH arm. Patients and methods: Title Author FOA Number Priority Area In vivoO MRS imaging - Quantitative assessment of regional oxygen consumption and perfusion rates in living brain. To investigate the impact of overall treatment time (OTT) of whole-brain radiotherapy (WBRT) with 5×4 Gy on outcomes. A retrospective study of patients with cytologically and histologically diagnosed NSCLC and brain metastasis detected by cranial computed tomography or magnetic resonance imaging was performed. Since September 1980 we have been conducting a prospective randomized trial to determine the best treatment schedule for radiation therapy (XRT) on brain metastasis from lung carcinoma. All patients received 3000 cGy of whole brain radiotherapy (WBRT). Boost delivered after WBRT by a conventional particle accelerator could provide a benefit in selected patients, especially for centers that do not have radiotherapy techniques in stereotactic conditions. Poor prognostic factors included advanced age (P < 0.04) and evidence of impaired consciousness, i.e., disorientation, lethargy, stupor, or coma (P < 0.007). Central nervous system Treatment per patient amounted to 0.8 courses of whole-brain RT, 0.2 neurosurgical procedures, 0.1 radiosurgical procedures and 1.3 cycles of chemotherapy. The total dose of WBRT was only 2,500 to 3,900 cGy, but daily fractions of 300 to 600 cGy were employed. Median overall survival was 5.6 months and survival rates at 1 and 2 years were 22.7% and 10%, respectively. Survival and prognostic factors, Recursive Partitioning Analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials, Sundstrom JT, Minn H, Lertola KK, Nordmann EPrognosis of patients treated for intracranial metastases with whole-brain irradiation. Oral metronidazole given every other day during radiation therapy provided no clinical benefit for patients with brain metastases compared to radiotherapy alone. The OS rates at 6 months were 17% after 10 x 3 Gy and 50% after 20 x 2 Gy/15 x 3 Gy (p = 0.014). Correspondingly, a large difference in actuarial median survival was observed (39.9 months [95% confidence interval, 16.8-63.0 months] versus 9.7 months (95% confidence interval, 6.1-13.3 months). The most common side-effects of lonidamine were myalgia, testicular pain, anorexia, and ototoxicity; however, only 2 patients had to discontinue the drug because of intolerable myalgias. Here we retrospectively evaluated whether chemotherapy re-administration (CT-R) was effective in patients after chemotherapy-induced ILD. The average age in both groups was 60 years; nearly two-thirds of all patients had lung primaries. Until proven otherwise, the treatment of choice for the majority of patients still remains a conventional palliative course of 3.0 Gy x 10 fractions. Symptom scores for fatigue and drowsiness increased significantly (51.1 vs 74.9, respectively 37.1 vs 70.4), indicating worsening of symptoms. The primary site, age, performance status, number of brain metastases and the presence of extracranial disease were studied as prognostic factors for survival. In many patients with brain metastases, the primary therapeutic aim is to accomplish symptom palliation and maintenance of Background/aim: See what Nancy Topping (nancytopping77) has discovered on Pinterest, the world's biggest collection of ideas. The estimated cost of radiotherapy, including retreatments and nonmedical costs, was statistically significantly lower for the single-fraction schedule than for the multiple-fraction schedule ($2438 versus $3311, difference = $873, 95% confidence interval [CI] on the difference = $449 to $1297; P<.001). Peer Reviewed http://deepblue.lib.umich.edu/bitstream/2027.42/45380/1/11060_2004_Article_BF00178115.pdf, A controlled randomized study was carried out to evaluate the effects of chemotherapy in patients with brain metastases from lung carcinoma. We studied whether neural processes containing nitric oxide synthase (NOS) are associated with large cerebral arteries and/or intraparenchymal microvessels. Certain authors evaluated various radiation schemes and were unable to detect improved survival if patients were treated with a total dose >30 Gy (27), ... We were surprised to discover that very few patients (8%) had time intervals of at least 36 months. The societal values of life expectancies were assessed with the EuroQol classification system (EQ-5D) questionnaire. Control of clinical neurologic status during follow-up was achieved in a greater proportion of asymptomatic patients (80%) than symptomatic patients (40%). Fifty-four patients completed the planned treatment. Mitochondrial Metabolic Medicine PurposeTo assess the potential benefit of a boost in patients treated with whole brain irradiation by a conventional linear accelerator for lung cancer solitary brain metastasis. In: Steel GG, editor. As focused ultrasound for blood–brain barrier disruption (FUS-BBBD) has progressed to human application, it has become necessary to consider the potential effects of prior irradiation treatments. 18 ก.ค. Overall, 11,532 patient days were analyzed. Reports indicate that patients that undergo standard fractionated cranial irradiation and stereotactic radiosurgery may have acute brain reactions in the range of 2–40% [1–12]. to evaluate the role of whole brain radiotherapy (WBRT) and radiation boost (RB) for 208 patients recursive partitioning analysis (RPA) II with 1 or 2 brain metastases (BM) at a single institution. However, there was a significant difference in favour of arm B for the time to brain progression (p = 0.028, Wilcoxon test). A trend was observed for KPS > or = 70 (p = 0.08) and less than four brain metastases (p = 0.06). Losses may be either accidental or controlled, the latter resulting from a decision to terminate certain observations. The 6-month local control rates were 12% and 10%, respectively (p = 0.32). Prognosis of patients treated for intracranial metastases with wholebrain irradiation. Overall survival (OS) and BM progression-free survival (BM-PFS) were analyzed using the Kaplan-Meier method and log-rank test. patient’s overall status must be considered when deciding on optimal therapy. In: Cranial irradiation in any condition can cause brain injuries that are classified into three groups based on the timing of their occurrence after radiation exposure: acute (during radiation or up to 6 weeks after radiation), early delayed or subacute (up to 6 months after radiation), and late delayed (6 months or more after the completion of radiation). Advances in conformal radiotherapy have created the possibility of avoiding certain areas of the brain linked to long-term deficits such as the hippocampus. – Fotemustine plus whole brain irradiation delayed the time to brain progression of melanoma cerebral metastases compared to fotemustine alone but without a significant improvement in terms of objective control or overall survival. A short course (30 Gy/ten fractions/two weeks) is an advantageous XRT because of the short treatment time for normal LDH and neurological improvement and minor toxicity for the high LDH group, while an optional treatment may be necessary for the selected patients. There was no significant difference in response rate or survival between the treatment groups. Clinical experience has shown that lonidamine is well-tolerated, and appears to potentiate the activity of conventional chemotherapy in the treatment of brain metastases. Patients and methods: On multivariate analysis of LC, higher WBRT dose was significant (p = 0.028). Und Ergebnisse der stereotaktischen hypofraktionierter Strahlentherapie prim chanikarn facts are submitted to alternative or palliative treatments achieve maximum value the. History and results of stereotactic radiosurgery of brain metastases undergo surgery: many submitted..., Bangkok, Thailand Fortschritte in der postoperativen Situation, dar start WBRT! 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